Bone Metabolism and Serum Osteocalcin in Osteoporotic Rats: The Role of Quercetin

Abstract

Osteoporosis has been steadily increasing in prevalence among humans. Decline in the structural integrity of 
bones and soft tissues is the primary cause of this prevalent illness, which significantly impacts the quality of 
life for older individuals. One of the most popular medications for osteoporosis is quercetin, a flavonoid. 
Research into quercetin's pharmacological and therapeutic effects is, hence, crucial. Discover how quercetin 
affects bone metabolism and serum osteocalcin in rats with osteoporosis is the goal of this paper, which also 
aims to address certain issues with quercetin's therapeutic use. For this study, we developed an animal model 
of osteoporosis using 90 rats. Each group of animals received either a sham surgery, an ovariectomy, or 
quercetin for observation. Every rat in the study had an ovary removed, with the exception of the ones in the 
sham surgery group. Those rats in the quercetin observation group also received quercetin medication. One 
week after that, we measured the levels of serum osteocalcin and bone metabolism in all of the rats and made 
note of any relevant data. The study's findings demonstrated that quercetin improved the bone mineral density 
and tissue structure of osteoporosis rats, as well as raising their bone metabolism index from 53.49±3.41 to 
86.27.2±4.22. It also raised their serum calcium level from 16.28±0.56 μg/l to 37.64±2.35 μg/l. It is clear that 
quercetin has beneficial effects on the treatment and prevention of osteoporosis, as well as on the promotion 
of bone metabolism in rats with osteoporotic bone disease.