DESIGN AND EVALUATION OF OMEPRAZOLE MULTI UNIT PELLET SYSTEM
Keywords:
Omeprazole, HPMC E5, Extrusion-Spheronization, Solution/Suspension layering, MUPSAbstract
The work was aimed to persude the Oral drug delivery system becomes challenging when the drug product needs to be delivered in
modified release pattern in elderly patients, especially since it is difficult to swallow for them. Multiparticulates are the choice of dosage
form when fast disintegration is desirable without loss of original release profile. The effect of sugar spheres containing enteric coated
pellets of Omeprazole. Multiple unit dosage forms of Omeprazole were formulated by Wurster process. The sugar spheres were coated
with the drug, HPMC E5, Eudragit L30D55 and then with PEG6000. The Optimized formulations showed plastic deformation and
maintain their integrity with no considerable change in their surface properties. In vitro release profile of formulation F9 containing
sugar spheres coated with, Eudragit L30D55 and PEG 6000 as cushioning agent showed release up to 97% at the end of 45 Mins in
buffer. The results prove that there is no potent incompatibility between the drug and the polymer. The F9 formulation was best suited for
multiple unit pellets systems of Omeprazole.
