Corchorus olitorius extracts: An initial pharmacological screening for anti-inflammatory and wound-healing properties

Abstract

The current study's objective was to look into the early screening of aerial Corchorus olitorius extracts for 
their ability to reduce inflammation and mend wounds in laboratory animals. Through serial solvent 
extraction, many extracts including the appropriate solvents—petroleum ether, chloroform, ethyl acetate, 
ethanol, and aqueous extracts of C. olitorius—were produced. Mice with Xylene-induced ear edema were used 
to screen all extracts for anti-inflammatory activity, and an incision wound model was used to examine the 
extracts' ability to cure wounds. The anti-inflammatory impact was found by weighing the ear lobes and using 
biochemical tests, nitric oxide (NO) levels, and MPO in the tissue sample. Tensile strength measurements and 
analyses of the protein and hydroxyproline levels in the repaired tissues were used to quantify the impact of 
wound healing. The current study's observations supported the finding that mice's ear edema was significantly 
(p<0.05) inhibited by C. olitorius ethanol extract (EECO). The mice treated with EECO showed a considerable 
reduction in both NO and MPO activity. Significant improvements in the tensile strength, protein content, and 
hydroxyproline level of the repaired tissue of the mice treated with EECO demonstrated the wound healing 
ability of the tissue. In conclusion, it was shown that the ethanol extract of C. olitorius exhibited the greatest 
anti-inflammatory efficacy by reducing both NO and MPO activity as well as the ability of experimental 
animals to repair wounds