Hepatoprotective Effects of Dawa-Ul-Kurkum, a Unani Polyherbal Preparation and the Possible Mechanisms in Experimental Model of Ethanol Induced Liver Damage in Rats

Abstract

Necrosis, elevated oxidative stress indicators such the Nitrates and Nitrites (NOx) test, 
Malondialdehyde levels, decreased glutathione (GSH) levels depletion, and elevated liver markers are all symptoms 
of hepatotoxicity. Methods: Hepatic derangement and an increase in several liver indicators were induced in rats by 
daily dosing with ethanol, simulating the effects of ethanol poisoning in humans. The effectiveness of various 
pharmaceutical interventions was evaluated using several indicators of liver damage. In addition, hepatic necrosis, 
fatty alterations, and hydropic degeneration were seen during histological analysis. A comparison of the 
hepatoprotective benefits of Dawa-ul-Kurkum and Hydro-alcoholic extract therapy with those of conventional 
medicine treatment showed similar outcomes for both. Higher levels of Malondialdehyde and Nitrates and Nitrites 
(NOx) test were found in alcoholic liver injury, but reduced glutathione (GSH) levels were found to be lower. Dawaul-Kurkum and Hydro-alcoholic therapies both reduced oxidative stress, although to varying degrees. The results 
show that Dawa-Ul-Kurkum therapy and its extract were effective in lowering hepatotoxic damage indicators in rats 
exposed to ethanol.