University Health Centre XDR Monitoring Randomised Control Trial

Abstract

Background: In order to analyze the rising trend of XDR colonized/infected individuals from both the 
community and hospital settings, the research zeroed in on patients with XDR organisms and risk 
factors. The research used a tertiary care hospital's periodic observational study as its methodology. 
Previous hospital-identified changes in antibiotic resistance patterns informed the periodic duration 
selection. December 2018–January 2019 and May 2019–June 2019 and November 2019–December 2020 were
the selected time periods. Even though it was a prospective research, in order to get the data, there 
was no sampling or experimentation. The patient's medical record and the microbiology lab provided
all the necessary facts. The results show that, out of the entire culture material, 5 -6% were XDR
isolates. Among the organisms we examined, Klebsiella accounted for 70%. As time went on, the 
number of infected patients increased, although colonization was initially greatest. Prolonged exposure 
to antibiotics (>50%), prior hospitalization (>40%), catheter (70%), a nd advanced age (mean age58.2 years) were the most significant risk variables acknowledged. The average length of stay in the 
hospital was three times longer than that of a typical hospital stay. Despite several prospective studies 
looking at the link between antibiotic exposure details and resistance development, it has proven 
difficult to isolate specific parameters relating to previous antibiotic exposure and resistance.