DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHODS FOR THE DETERMINATION OF RISPERIDONE IN PURE AND TABLET DOSAGE FORMS

Abstract

A straightforward and very accurate visible 
spectrophotometric technique is presented for 
the measurement of pure and solid dose forms of 
risperidone (RSP). 
Using an oxidative coupling process, risperidone 
and MBTH are combined in the presence of 
dissolved ferric chloride in HCl to generate 
apple green chromogen, which has an absorption 
peak at 595.8 nm. A Beer-Lambert plot 
regression analysis revealed strong association 
in the concentration ranges of 10–80 μg/mL. 
The regression coefficient of 0.992 was 
discovered. The suggested approach is used on 
commercially available tablets, and recovery 
studies are used to statistically analyze and 
verify the outcomes. Both the drug's tablet dose 
form and its mass have been effectively 
analyzed using the suggested methodologies. 
After statistical analysis, the procedures were 
determined to be exact and correct