NOSE TO BRAIN A MUTLIFACETED MODE OF DRUG DELIVERY SYSTEM

Abstract

It has always been difficult to treat 
neurodegenerative illnesses and other 
abnormalities of the central nervous system 
(CNS). Due to the blood-brain barrier's 
(BBB) nature, therapeutic molecules cannot 
fully penetrate the brain after being 
administered orally or parenterally. This, 
along with hepatic metabolism, drug 
elimination, and drug inactivation during 
the drug's journey through the systemic 
circulation, reduces treatment efficacy, 
necessitates high dosages, and frequently 
results in unfavorable side effects. Drug 
concentration in the brain is increased 
through nose-to-brain delivery, which 
circumvents the blood-brain barrier and 
permits the direct movement of medicinal 
compounds. The processes of nose-to-brain 
drug delivery are described in this study, 
along with recent developments in the field, 
with a focus on techniques based on 
nanotechnology