Stability indicating RP-HPLC method development and validation of Terbinafine inpure and pharmaceutical formulation

Authors

  • M. Lakshmi Surekha Author
  • Bharghava Bhushan Rao P Author
  • R. Sunitha Author
  • Padma R Author
  • Jhansi Rani M Author
  • Suresh Kumar E Author

Keywords:

Terbinafine HCl, Stability Studies, RP-HPLC, PDA Detection, Tablet dosage forms, ICH guidelines

Abstract

A high performance liquid chromatographic strategy for the assessment of TerbinafineHCl from formulation was created.
TerbinafineHCl was chromatographed on a Inertsil ODS-3V (250×4.6, 5µm) and having an inner measurement of 3.9 mm. 
Mobile phase involving Mobile phase Acetonitrile : 2% IPA (80:20), Mobile phase. The pH of the buffer adjusted to 3.5. The
detection was carried out using an ultraviolet detector set at a wavelength of 260 nm. The technique was extended for the
stability studies of TerbinafineHCl.

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Published

25-06-2019

How to Cite

Stability indicating RP-HPLC method development and validation of Terbinafine inpure and pharmaceutical formulation. (2019). Indo-American Journal of Pharma and Bio Sciences, 17(2), 1-8. https://iajpb.org/index.php/iajpb/article/view/23