Stability indicating RP-HPLC method development and validation of Terbinafine inpure and pharmaceutical formulation
Keywords:
Terbinafine HCl, Stability Studies, RP-HPLC, PDA Detection, Tablet dosage forms, ICH guidelinesAbstract
A high performance liquid chromatographic strategy for the assessment of TerbinafineHCl from formulation was created.
TerbinafineHCl was chromatographed on a Inertsil ODS-3V (250×4.6, 5µm) and having an inner measurement of 3.9 mm.
Mobile phase involving Mobile phase Acetonitrile : 2% IPA (80:20), Mobile phase. The pH of the buffer adjusted to 3.5. The
detection was carried out using an ultraviolet detector set at a wavelength of 260 nm. The technique was extended for the
stability studies of TerbinafineHCl.











