FECAL MICROBIOTA TRANSPLANTATION

Abstract

FMT is a method used to directly change the recipient’s gut microbiota to normalize the composition and gain a therapeutic benefit for treating recurrent and 
refractory Clostridium difficile infections . Clostridium difficle colitis is the inflammation of the colon results from the disturbance in normal, healthy bacteria in the 
colon, often as a result of excessive use of antibiotics. Symptoms of clostridium difficle colitis are diarrhoea, nausea, bloating, blood in stool, high body temperatures, 
signs of dehydration such as dry mouth, headache, loss of appetite and weight loss. FMT can be done through colonoscopy, a procedure that enables a doctor to 
examine the colon using a long, flexible tube with a camera and light on the end . The stool sample is placed in the tube, or colonoscope, and the colonoscope is 
inserted into colon through the anus . It slowly reaches the colon . Once it reaches the end of the colon, the doctor releases the stool sample . It showed a success rate 
of 88% after a single FMT whereas 93% after multiple FMTs. Most of the short term risks are mild and known to be associated with delivery methods. Stool banks 
safely collects, stores and distributes the stool samples for the treatment of CDI, and also participates in the research studies under stern protocols