INTERNATIONAL JOURNAL OF UNIVERSAL PHARMACY AND BIO SCIENCES

Abstract

Ipomoea carnea Jacq (Convolvulaceae), locally known as 
Beshram and is used traditionally and having sedative 
hypnotic property. Ipomoea carnea appears to fall under the 
sedative-hypnotic category of central depressants activity, so 
the present work was undertaken to investigate the anxiolytic 
activity by using scientific models. The anxiolytic effects of 
the aqueous and methanolic extract of Ipomoea carnea leaves 
(32.50 and 16.25mg/kg i.p.) was evaluated in mice using 
elevated plus maze, open field test and hole board test 
models, diazepam was used as positive standard. The intraperitoneal (i.p.) LD50 of the Ipomoea carnea leaf aqueous 
extract (ICLAE) and Ipomoea carnea methanolic extract 
(ICLME) in mice was found to be 325 mg/kg i.p. body 
weight. Administration of ICLAE and ICLME at doses 
32.5mg/kg, 16.2mg/kg significantly increased time spent in 
open arms, number of entries in open arms and percentage 
entries in open arms of the elevated plus maze. Treatment of 
ICLAE and ICLME at doses 32.5mg/kg, 16.2mg/kg) 
significantly increased the number of crossed squares, 
decreased the immobility, and decreased the fecal pellets in 
open field test. ICLAE and ICLME at doses 32.5mg/kg, 
16.2mg/kg) significantly increased the hole-poking response 
in hole board test. All results are compared to vehicle and 
diazepam as a standard drug for anxiolytic activity. ICLME
showed greater anxiolytic effect as compared to ICLAE 
(doses of 32.5mg/kg and 16.2mg/kg) and diazepam