Skin cancer patients undergoing etoposide, prednisolone, vincristine, and cyclophosphamide therapy may have hyperpigmentation of the teeth and tongue.

Abstract

Chemotherapeutic medicines such as etoposide, vincristine, and cyclophosphamide are
often used to treat the uncommon malignancy known as cutaneous extranodal non-Hodgkin
lymphoma. These drugs very infrequently produce hyperpigmentation in the skin and nails. Here,
however, we report an instance of hyperpigmentation that spread to the teeth and tongue. It
wasn't long after chemotherapy started that the tongue and teeth began to hyperpigment. No
pharmaceutical, surgical, or lifestyle therapies were necessary for the hyperpigmentation to
resolve itself within a week.