FORMULATION AND EVALUTION OFORLISTAT LIQUISOLID TABLETS

Abstract

Orlistat is an almost insoluble anti-obesity drug; this study aimed to apply the liquisolid technology to increase its solubility. Orlistat was dissolved in
Polyethylene Glycol, and then different liquisolid tablets were made by using Avicel PH 102 as the carrier, Aerosil 200 as the coating material, and
Sodium starch glycolate as the disintegration agent. The formulations included dissolving agents such polyvinyl pyrrolidine, hydroxypropyl
methylcellulose, and hydroxypropyl guar. Calculations were made using the liquid load factor for the liquid vehicle to determine the optimum
quantities of carrier and coating materials required to create suitable flowing and compactable powder admixtures feasible for tablet formation. The
resulting liquisolid tablets were analysed after compression for properties such as weight variation, hardness, friability, drug content, and in-vitro
dissolving tests. The medicine and excipients were not identified to have any chemically significant interactions in the FT-IR analysis. The drug's
transformation from crystalline to amorphous form in liquisolid tablets was confirmed by differential scanning calorimetry. Orlistat pills in liquid
form exhibited greater wetting qualities and a larger surface area accessible for disintegration, allowing them to release more medication than
directly broken tablets. This research shows that liquisolid technology has the potential to increase the water solubility of medications that are just
slightly soluble in water