FORMULATION AND EVALUATION OF APIXABAN ORIDISPERSIBLE FAST DISSOLVING TABLETS

Abstract

Different Apixaban tablets were prepared by incorporating various excipients, such as PEG 600 by melting method PEG is used as a
lubricant, microcrystalline cellulose as a diluent, sodium starch glycolate as a capsule disintegrant, mannitol as a sweetening agent, and
magnesium as a capsule lubricant. The work was done to improve the dissolution properties of the practically insoluble anticoagulant
drug Apixaban. It was determined that post-compressional criteria such weight fluctuation, hardness, friability, drug content, and in
vitro dissolving experiments were all favourable for the development of Apixaban tablets. Research using Fourier transform infrared
spectroscopy (FTIR) indicated no chemical interaction between the medication and excipients. These findings highlight a key advantage
of Apixaban tablets over directly compressed ones: a higher percentage of drug release due to their superior wetting qualities and larger
surface area for drug disintegration. This research shows that the solid dispersion approach is a viable option for increasing the water
solubility of medications that are otherwise difficult to dissolve in water