FORMULATION AND EVALUATION OF ITRACONAZOLE IMMEDIATE RELEASE TABLETS

Abstract

The current study aimed to develop and evaluate a novel super disintegrant containing chitosan silicate conjugate
and chitosan thioglycolic acid conjugate for the rapid release and absorption of the anti-fungal medication
itraconazole following oral administration, and to compare it to other commercially available super disintegrants
such as sodium starch glycolate. The Charring point, Viscosity, and Fourier transforms of chitosan thioglycolic acid
and chatoyant silicate conjugates, which were used to make the tablet, were determined. Medicine compatibility was
tested using techniques including Fourier transform infrared spectroscopy and differential scanning calorimetry, and
no negative interactions were found between the drug and its intended receivers. In this study, we analyzed the postcompression properties of rapid release tablet formulations made utilizing the direct compression technique. This
research found that the disintegration time of tablets given orally is shorter than that of those delivered sublingually,
leading to faster absorption and greater bioavailability. Since formulation F-6 needed less time to wet and absorbed
more moisture than tablets with the same proportions of SSG, CTC, and starch, it was deemed the best option. The
in vitro dissolving tests showed that after 30 minutes, F-6 had disintegrated to its full potential thanks to the
extraordinary disintegration capacity of the Chitosan silicate conjugate. The procedure for releasing was first-order
and non-Fictional. F-6 was found to be stable after being put through a battery of stability tests, passing with flying
colors in terms of both visual appeal and its capacity to dissolve and disintegrate in vitro