FORMULATION AND EVALUATION OF CONTROLLED RELEASE VITAMIN “C” MICROPARTICLES

Abstract

With the use of cellulose polymers such hydroxypropyl methyl cellulose, cellulose acetate phthalate, and ethyl cellulose, the current work
aims to produce vitamin C microparticles. Microparticles were produced utilising the Emulsion Solvent Evaporation Technique. To
evaluate the physicochemical characteristics of vitamin C microparticles, techniques such as FTIR, frequency distribution analysis,
percent drug entrapment efficiency, in vitro drug release, and release kinetics were applied. The FTIR spectrum showed that polymers and
pure medicines could coexist. It was possible to obtain the typical frequency distribution of the vitamin "C" microparticles. Maximum
drug entrapment effectiveness was attained in Vitamin "C" Microparticles at 98.7%. The performance of vitamin "C" microparticles in a
test tube showed that the concentration of polymers affected control release. Regression coefficient values indicate that the data were
published with an order of 0. According to the study, the polymers used had an effect on how much Vitamin "C" was released from the
small particles. It was shown that the used cellulose derivatives restricted the medication release. Among the cellulose derivatives tested,
ethyl cellulose microparticles with a core:coat ratio of 1:1 were shown to have a better controlled release of vitamin "C" over a period of
12 hours.