Development and Evaluation of Swellable Elementary Osmotic Pump Tablet of Glipizide

Abstract

The medicine glipizide, which is not particularly water-soluble, may now be efficiently delivered with the help of a new kind of tablet called an 
elementary osmotic pump (EOP). A drug is released from the system via a delivery orifice in the form of a fine dispersion, prepared for 
absorption and dissolving, by use of the Swellable Elementary Osmotic Pump [SEOP]. SEOP tablets were made by compressing a convex 
tablet containing a combination of micronized medication and excipients. Wet and swelling agents, osmotic agents, and hydrophobic 
plasticizers were studied for their effects on release rate. For 24 hours, researchers looked at how several formulations of this dosage form 
released glipizide at a pH of 6.8. Data collected from osmotic devices revealed that the medication release profile is quite sensitive to the core 
formulation's polymer type. A reduction in medication release was seen when the dosage of HPMC E50-LV was raised from 30 to 60 mg. By 
increasing the quantity of wetting agent to 45 mg, the release rate and zero order release pattern of glipizide were much improved. Although 
the device's semipermeable membrane attenuated glipizide release at concentrations ranging from 20% to 30% dibutylphthalate, the highest 
efficacy was achieved at this concentration. The optimal orifice diameter was determined to be 500 μm according to the SEM investigations. 
The 24-hour release rate of GF2 was superior to that of the commercially available Glipizide extended release tablet. There was a strong invivo and in-vitro association for GF2 as seen by the greater Cmax and AUC values, according to the bioavailability experiments conducted on 
albino rabbits for glipizide SEOP and Glipizide extended release tablet. Therefore, glipizide was effectively administered over the course of 24 
hours using a newly developed SEOP that achieved zero-order drug release.