Anticancer effect of Andrographolide in oral squamous cell carcinoma cell lines - A Systematic Review

Abstract

Background
Andrographolide, a plant extract of Andrographis paniculata has shown promising cytotoxic 
effects on various cancer in-vitro and animal studies. However, there is scarcity of evidence of 
its anticancer effect on oral squamous cell carcinoma. Hence, it is important to gather evidence 
aaavailable in literature.
Methods:
Comprehensive databases were used to retrieve the articles. Studies fulfilling the eligibility 
criteria were included. Due to heterogeneity in methodology, meta-analysis was not attempted. 
Quality assessment was carried out using ToxRTool, analyzing the toxic effect of agents. 
Results:
Six studies have met the inclusion criteria. These studies demonstrated that andrographolide and 
its combination with silver lipid nanoparticles and cisplatin is important in inhibiting cell 
proliferation, cell cycle arrest, apoptosis and regulating proteins involved in carcinogenesis 
pathways.Hence, combination of andrographolide with nanoparticles shows better potential 
anticancer effect in OSCC cell lines.
CONCLUSION:
Andrographolide has shown anticancer effects in OSCC and lesser IC50 values which ultimately 
lead to inhibiting the proliferation of tumor cells. Hence, andrographolide with nanoparticles will 
exhibit better cytotoxicity in lower concentration.Further studies , combination with standard 
chemotherapeutic drugs should be explored to increase their cytotoxic potency.