Featured Compilation on Progress in Drug Testing and Formulation Sciences

Abstract

Goal: In accordance with ICH guidelines, a straightforward, accurate, fast, and cost-effective reverse phase high-pressure liquid chromatographic technique has been created for the measurement of naproxen in pharmaceutical formulations. Techniques: A Kromosil-C18 ODS column (150 mm x 4.6 mm; 5 µ) was used for the procedure. The mobile phase was made up of methanol (40:60 v/v) and ammonium acetate buffer (pH 4.0 adjusted with 1% triethyl amine), which was then filtered with 0.45 µ cellulose nitrate filters. In isocratic mode, the flow rate was kept constant at 1.0 mL/min. At 210 nm, the detection was performed. It ran for 7.0 minutes.

Results: Naproxen had a retention time of 3.063 minutes. Accuracy, precision, linearity, limit of detection, limit of quantification, and solution stability were all evaluated for the proposed technique.

Conclusion: For the measurement of naproxen in both bulk and tablet dose forms, the suggested approach was sufficient in terms of sensitivity, reproducibility, and specificity.