Activity of Alternantherasessilis (Linn.) R.Br.Ex DC Against Bacteria and Fungi

Abstract

The current study set out to test the antibacterial capabilities of an extract from Alternanthera sessilis leaves using chloroform and methanol as solvents against a variety of bacteria, fungi, and Gram-positive and Gram-negative strains. The soxhlet apparatus was used to extract the Alternanthera sessilis (Linn.) R.Br.ex DC (Family Amaranthaceae) leaves thoroughly. The antimicrobial efficacy of Alternanthera sessilis extracts was tested using the well diffusion technique against a variety of bacterial and fungal species, including MTCC723, MTCC902, Candida albicans, and Aspergillus fumigatus. For comparison, standard antibiotics like ciprofloxacin and fluconazole were used. The methanol extract showed encouraging antibacterial activity, against E. coli, Staphylococcus aureus, Candida albicans, and Aspergillus fumigatus, with inhibition zones of 16 mm, 9 mm, 12 mm, and 14 mm, respectively. In contrast, a zone of inhibition of 10 mm was seen against E. coli in chloroform extracts. Within the concentration range of 50 to 100 μg/ml, the antibacterial activity of the extract was shown by the MIC analysis against the tested strains of microorganisms. According to the ayurvedic literature, Alternanthera sessilis Linn. aerial parts may be helpful in treating a number of pathogenic disorders. This research supports that claim. The antibacterial action was attributed to the presence of several phytochemical elements in the leaf extracts of Alternanthera sessilis. Phytochemicals, chloroform, methanol, antifungal activity, and Alternanthera sessilis are some of the terms used to describe this plant.